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Thus, a number of groups have shown that virus infection can be “sensed” by MAIT cells and a functional response invoked. Mucosal associated invariant T cells (MAIT cells) bear a T cell receptor (TCR) that specifically targets microbially-derived metabolites. We propose that MAIT cell-mediated cytotoxicity can be induced, bolstered, or restored to assist in clearing infections and potentially in reducing tumor loads.
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The five employees are among 15 people who have pleaded guilty or been convicted at trial “Finally, it is perhaps best to focus on the family, as it is usual that parents of overweight children are themselves overweight
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We also demonstrate a positive association between the frequency of MAIT cells and other unconventional T cells including Natural Killer T (NKT) cells and Vδ2⁺ γδ T cells. Moreover, while all MAIT cell subsets produced comparable levels of IFNγ, TNF and IL-17A, the CD4⁺ population produced more IL-2 than the other subsets. For example, a study of HIV-infected individuals suggested that MAIT cells may lose expression of CD161 upon activation, 37 and many reports suggest a reduction in MAIT cells defined by these surrogate markers in disease settings, 27,28,   and in the context of aging. Future studies in this field should address the challenge of studying tissue-resident cells, particularly in the gut, and better defining the determinants of MAIT/iNKT cell dysfunction. This underscores the importance of research on restoring these unconventional T cells during HIV infection.