Can pantoprazole combined with levosulpride gives the effective cure in gerd patient?

First of all, patient consultation was done, data was collected and an endoscopy test was done before starting treatment. Then, treatment was initiated with levosulpiride or itopride twice daily before meals.


Symptomatic relief and endoscopic recovery is early with levosulpiride than itopride. Levosulpiride gives better quality of life earlier in the treatment than itopride and has lesser side effects and better healing outcome. The aim of the study is to assess the safety and efficacy of levosulpiride and itopride in the management of GERD and to study the side effects and treatment outcome. This study was a prospective interventional study carried out at a teaching public hospital in Mumbai from May 2010 to September 2012 after obtaining the institute’s ethics committee approval.

Quality of life was assessed using the SF-36 questionnaire. Among the patients who were operated, the SF-36 score for quality of life did not show statistically significant change in all the eight parameters after 3 months of conservative management. The mean score for all the 8 parameters of quality of life showed improvement at 6 months after surgery. This increase was statistically significant in the areas of social functioning, pain, and general health. Among the patients who were managed conservatively, there was statistically significant improvement in score for physical functioning, role limitation due to physical health, role limitation due to emotional problems, emotional well-being, social functioning, and general health at 3 months.

Follow up was done and any adverse drug reactions were noted and finally at the end of two weeks outcome was assessed. Levosulpiride is a prescription medicine for conditions like GERD, IBS, Indigestion, Depression, and Dyspepsia. It belongs to the class of medications called atypical antipsychotic drugs.

Indigestion issue, vomit some after eating, sometime vomit all food. Have generalized anxiety issue also since 2014 with panic. But stomach also disturb when eat spicy food or even sometimes non spicy home food. Vomiting nausea feeling. Headaches too. Taking medicine xanax 0.25 mg per day for anxiety as by doctor but stomach problem is always there taking levosulpiride 25 mg and it gives relieve alot never been to endoscopy for stomach but doctor said it’s gerd symptoms. Doing night shift job sleep in day timing. Sleep 5 6 hours daily. habits:lye down after eating fear of having caner in stomach

levosulpiride for gerd

Contributing factors include the caustic materials that are refluxed, a breakdown in the defense mechanisms of the esophagus and a functional abnormality that results in reflux. Alginate controls heartburn in patients with erosive and nonerosive reflux disease.

Psychiatry finally had some medical tools to help these patients. It was soon realized that this category of drugs also had a wide application.

  • Overall, there were 30 patients who were still symptomatic (60% cases) after three months of conservative management.
  • These complications occurred in the initial period of the study, demonstrating that there is a learning curve in laparoscopic surgery.
  • The levo enantiomer shows better/similar pharmacological actions and lower incidence of toxic effects than both dextro as well as the racemic forms of the drug.

In 2006, a large Japanese multi-centre clinical trial using mosapride in the treatment of functional dyspepsia was published. Mosapride demonstrated effectiveness, substantially reducing the feelings of abdominal discomfort and fullness.

levosulpiride for gerd

Levosulpiride side effects

At 6 months after surgery, 96.6% patients showed a normotensive lower esophageal sphincter compared to all patients showing hypotensive sphincter before surgery and this change was statistically significant. There was a statistically significant increase in the distance of lower esophageal sphincter from central incisors after surgery. Lower esophageal sphincter relaxation remained complete both pre- and postoperatively in 100% cases. Hiatal hernia which was present in all cases (100%) pre-operatively was totally absent postoperatively (100%) and this difference was statistically significant. These findings were in accordance with those obtained by Wileman et al. [9].

These findings were similar to those obtained in the review of four trials by Wileman et al. [9]. Heartburn (94%) and regurgitation (92%) were the most common symptoms at the time of diagnosis. Dysphagia (16%) was uncommon. Angina like chest pain and respiratory symptoms (cough and hoarseness) were not seen (Table 1).

In October 1998, Dainippon Pharmaceutical Co. Ltd. launched mosapride citrate for the treatment of dyspeptic symptoms associated with chronic gastritis. Resolor in now available and on the market in the UK and EU countires for the treatment of chronic constipation.

Prokinetic medications help control acid reflux by strengthening the Lower Oesophageal Sphincter (LES), so that the contents of the stomach empty faster, thereby preventing the acid reflux. Levosulpiride and itopride are two such prokinetic drugs. When some medicine is used along with some other medicines they have a chance of interacting each other.

I got endoscopy 2.5 years ago in usa and was diagnosed with gerd and functional dyspepsia and told to take pantop and levosulpiride sos. Got routine blood work all normal – cbc, lft, kft,amylase, abdomen ultrasound, ecg. Should I get repeat endoscopy? Thanks.

levosulpiride for gerd

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