Mechanisms underlying reflux symptoms and dysphagia in patients with joint hypermobility syndrome, with and without postural tachycardia syndrome

This is the most common form of EDS, affecting as many as 1 person in 200 possibly, although most cases will be mild and undiagnosed. It is inherited but so far no gene has been identified as the cause.

It can be mild and is probably often undiagnosed. The main symptoms of hEDS are stretchy skin (which is not fragile but which may heal slowly) and unusually flexible joints.

GI symptoms refractory to these measures should prompt further diagnostic evaluation of gastrointestinal dysmotility and appropriate dietary and pharmacologic management. This review focuses its attention on the involvement of the GI tract in POTS including a discussion of GI symptoms and conditions associated with POTS, followed by an analysis of abnormalities in gut physiology described in POTS, and concluding with an overview of management and suggestions for research directions.. and concluding with an overview of suggestions and management for research directions.} Our study has several limitations. The first one is the absence of control group (except regarding GIQLI for which we used a historical control French population) which precludes definitive conclusions from this survey. However, there is an abundant literature about FBD and GERD and comparisons with reported natural frequencies and severity in historical populations allow us to assume that gastrointestinal manifestations in EDS are particularly common and linked to the condition.

Joint hypermobility is a very common condition, and many people with loose joints shall have no related medical problems at all. Most people have just a few, such as achy joints and cold feet and hands, and they should not be overly concerned that they will go on to develop other complications. On the other hand, I have described some of the more common conditions associated with hypermobility, because those who do have many related problems may be relieved to understand that there is a unifying explanation for so many of the unusual things they have noticed about their bodies. Beyond the psychological relief of understanding their symptoms, with proper treatment most people with JHS can get significant relief from their physical symptoms, too.

Have you experienced any unexpected symptoms as a result of EDS? Let us know in the comments below.

In these patients, EDS persists and the underlying cause is left undiagnosed. This small pilot study reveals that many patients with complaints of EDS and who were admitted to our Department of Hepatology and Gastroenterology due to a suspicion of liver disease actually had symptoms of GERD.

Lower GI symptoms: irritable bowel syndrome and functional constipation

Osteoarthritis of the knee joint itself is not as common, but it can occur, especially in those who have done years of high- impact exercise or who are overweight. Joint hypermobility syndrome, as the name implies, affects the musculoskeletal system primarily.

Using data pooled from 16 conducted clinical treatment trials independently, Carlsson et al examined the prevalence of heartburn symptoms in patients with or without erosive oesophagitis.9 Their meta-analysis convincingly showed that moderate to severe heartburn was as prevalent among patients with grade 1 (mucosal erythema) or grade 2 (non-circumferential erosions), with a respective prevalence of 71.7% and 75.8%, as patients with grade 3 (circumferential erosions) and grade 4 (oesophageal ulceration) where the prevalence of heartburn was 74.4% and 64.2%, respectively.9 Other symptoms, such as acid regurgitation, were also equally prevalent among patients with little or no mucosal injury and those with erosive oesophagitis . Functional heartburn is a common disorder and appears to be composed of several distinct subgroups. Identifying the different subgroups based on clinical history only is not achievable at present.

  • A relationship between GERD and daytime somnolence has been described in other studies.
  • In support of these recommendations, pantoprazole was found to provide more significant reductions in reflux symptoms and ESS scores than placebo after administration to patients with mild-moderate obstructive sleep-disordered breathing and GERD [27].
  • After surgery, gut artery blockage and other complications can occur in vEDS also.
  • The most frequently reported problems affecting the upper digestive tract are acid reflux and chronic/recurrent indigestion with pain or discomfort and early fullness after meals.
  • For most people, the distinction between joint hypermobility, joint hypermobility syndrome, and the hypermobile type of Ehlers-Danlos is not an important one clinically, as treatments are similar.

Read more about the symptoms of joint hypermobility and diagnosing joint hypermobility. Joint hypermobility is what some people refer to as having “loose joints” or being “double-jointed”. Spondylodysplastic EDS (spEDS) is a severe EDS. Like the other rare types, in order to inherit it you need to have inherited one faulty gene from EACH of your parents.

eds and acid reflux

EDS is now therefore called ‘the Ehlers-Danlos syndromes’. Whilst the most common form of EDS is mild and often goes undiagnosed as a result usually, for some people with EDS, symptoms can be severe. Some of the rarer forms are life-changing, even life-threatening.

Many people also have dizziness (vertigo). An uncomfortable feeling of thudding of the heart (palpitations) and noticeable extra beats are symptoms experienced by many people but they are more common in EDS. Many people experience dizziness and a fast pulse rate when they stand quickly. Many affected people find that their skin splits and bruises easily and that skin injuries heal slowly.

EDS is a group of inherited heterogenous multisystem disorders characterized by skin hyperextensibility, atrophic scarring, joint hypermobility, and generalized tissue fragility [3]. Hypermobile EDS (hEDS) is thought to be the most common type [4]. Recent studies have suggested an association between connective tissue hypermobility and functional gastrointestinal disorders (FGDs) [5-10]. Hypermobile Ehlers-Danlos syndrome (hEDS) is generally considered the least severe type of EDS, although significant complications, musculoskeletal primarily, can and do occur.

Some estimates suggest that around one in every five people in the UK may have hypermobile joints. If hypermobility occurs alongside symptoms such as these, it is known as joint hypermobility syndrome (JHS).

eds and acid reflux

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